Things in the library 20 Jan ...

New Things about TRIP....
One of Trip’s main aims is to help users find the best available evidence with the minimum of effort. The latest update has some innovative new features, all there to support your evidence search. Don't forget that for a second year you have access to PRO features by registering as NHS staff.

• Answer Engine. They’ve been discussing this for nearly five years and seriously working on it for over twelve months. Obtain instant answers to some clinical questions, seamlessly integrated in to your search experience.
• SmartSearch. An useful system to help speed up your search and to help users avoid missing important documents. They analyse the articles you click and use that to predict other articles that are highly relevant.
• Search suggestions. Incorporated in to your results allowing you to easily produce a more focused search.
• Broken links. Arguably a minor upgrade, but very important. Broken links can be a terrible user experience. Take out your frustrations by hitting the new ‘Broken link’ feature under each result.

Things about transition and epilepsy...

A recent article in Epilepsy & Behavior discusses 'The transition from pediatric to adult care for youth with epilepsy: Basic biological, sociological, and psychological issues'.  Below they summarise a few of the broad concerns that arise from this review.

• Brain development – Impulsive pleasure seeking and risky behaviour may be the result of an imbalance between frontal and limbic maturation and should be anticipated.
• Endocrinological development – Puberty has a major effect on development, personality, and behaviour.
• Sexual development – Peer relationship problems may interfere with normal sexual development. Sexual debut is early in youth with epilepsy and long-term sexual experiences are often unsatisfactory.
• Psychological development – Normal developmental stages in adolescence may be disrupted by epilepsy. While epilepsy may contribute to adjustment problems, some of these issues are related to normal developmental concerns. Family dysfunction has a strong effect on maturation of adolescents with epilepsy. Severe behaviour problems with intellectual disability and/or autistic spectrum disorder are not typically related to family dysfunction and have multiple etiologies.
• Bone health – The degree of risk for and mechanisms of bone disorders in childhood-onset epilepsy are unclear. For those at increased risk, serum vitamin D and DXA screening may be useful along with supplemental vitamin D.

Things about 3D printing of drugs for children....

An article this week in AAPS PharmSciTech discusses the potential for using 3D printing for paediatric drugs the abstract is below. This article is part of a topical collection on the theme Pediatric Drug Development and Dosage Form Design.

The first medicine manufactured by three-dimensional (3D) printing was recently approved by the Food and Drug Administration (FDA). The advantages of printing as a manufacturing route enabling more flexibility regarding the dose, and enlarging individual treatment options, have been demonstrated. There is a particular need for flexible drug delivery solutions when it comes to children. Printing as a new pharmaceutical manufacturing technology brings manufacturing closer to the patient and can easily be adjusted to the required dosing scheme, offering more flexibility for treatments. Printing of medicine may therefore become the manufacturing route of choice to provide tailored and potentially on-demand treatments for patients with individual needs. This paper intends to summarize and discuss the state of the art, the crucial aspects which should be taken into account, and the still-open questions, in order to make 3D printing a suitable manufacturing route for pediatric drugs.

Things about PKU...
A Key European guidelines for the diagnosis and management of patients with phenylketonuria was published in the Lancet recently. From the 70 recommendations formulated, in this Review they describe ten that they deem as having the highest priority.

An e-book for surgeons...
We have recently purchased an e-book copy of  the latest edition of Spitz Operative Pediatric Surgery for SCH staff. Follow the link and login with your free NHS Open Athens account.
Not a surgeon???.....then login to the e-book portal and search for what you are interested in. You can browse books free for 5 mins and if there is a resource which you think will be well used by your department ask us if we can purchase it.

Things with crunch...
As a quick easy and quite healthy dessert why not try these Honey nut crunch pears?  This recipe uses cornflakes but I expect other cereals would work well too!